Currents from inside the Pharmacy Training and LearningAsma Este-Magboub, Ian S
Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological needs and you may pharmacology off curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the big element of the fresh new yellow color from turmeric, a keen Indian liven that’s taken from the fresh rhizome of your exotic plant Curcuma longa, which belongs to the Zingiberaceae family members. Within this section, we talk about the pharmacological facts out-of curcumin and you Latvia naiset sivustot may explore the latest unit basics for those items. I then comment the confirmed and prospective clinical spends away from curcumin. Curcumin is famous over the years as a healing representative, but the procedure away from step try in depth. The brand new pharmacological aftereffects of curcumin be seemingly the consequence of a beneficial synergism out-of networks of weak biochemical interactions having numerous physiological aim in the interrelated signaling paths. These types of purpose is enzymes for example cyclooxygenase, lipoxygenase and you can proteins kinases, and transcription factors such as for example NF-?B, STAT and you can Nrf2. Modulation ones particles impacts downstream affectors that produce this new antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial things out of curcumin. These types of outcomes was indeed examined for the scientific trials away from curcumin having problems and inflammatory disorder, cancers, Alzheimer condition, aerobic sickness, and diabetes. Brand new trials purchased variable dosage out of curcuminwith different wavelengths and you may stage, to your general completion one to highest dosages regarding curcumin at quantity of g have to receive healing outcomes. Read more
Curcumin: Synthesis, Growing Role for the Soreness Management and you will Health Ramifications
Guide Section Examples of plant-derived pharmaceuticals which have get to be the attract off proceeded and you may great search and you will development attention possess, up to now, become a little scarce. Shortly after a long period, the final 2 decades was basically described as a good 100-fold upsurge in the number of scientific articles blogged a year one is actually from advantages for the usage of curcumin within the biomedicine. Find out more
Framework, synthesis and physical factors regarding curcumin prodrugs
Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has many prospective pharmacological outcomes and may enjoys therapeutic apps in several problem claims, since the talked about in detail in the previous section. Although not, the possibility scientific effectiveness out of curcumin is limited of the their physicochemical features from terrible water solubility and you may imbalance, which end in low bioavailability. Prodrugs out of curcumin give a means to improve of one’s biopharmaceutical and pharmacokinetic characteristics, that can allow it to be exploitation of your own pharmacological effects of curcumin. In this chapter, i first remark the latest physicochemical and you will pharmacokinetics of curcumin. We following establish the appearance of curcumin prodrugs having increased liquid solubility and enhanced toxins stability which can be translated back into free curcumin through to bioactivation from inside the vivo. We focus on present success in this field, with a concentrate on the construction, synthesis and evaluation out of prodrugs predicated on promoieties including proteins, fatty acids, nucleic acids, dicarboxylic acids, and you can polymeric product eg hyaluronic acid and you may polyethylene glycol. It section has the basis for optimization of physicochemical and you will biopharmaceutical characteristics therefore the physical circumstances regarding curcumin prodrugs, into the mission having fun with of those curcumin derivatives inside medical programs. Find out more
